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KMID : 0358920230500040421
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Journal of the Korean Academy of Pedodontics
2023 Volume.50 No. 4 p.421 ~ p.433
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Assessment of Risk Factors for Dental Developmental Disorders in Pediatric Cancer Survivors
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Lee Ji-Hyun
Choi Hyung-Jun
Lee Jae-Ho
Song Je-Seon
Kang Chung-Min
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Abstract
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This study was to examine the developmental dental abnormalities in childhood cancer survivors. Risk factors were assessed for 125 children with radiographic data through a retrospective analysis of medical records and panoramic images. 68.0% of childhood cancer survivors exhibited at least one dental abnormality. The types of abnormalities varied depending on the age at cancer diagnosis and treatment intensity, ranging from microdontia (43.2%), to abnormal root development (39.2%) and tooth agenesis (33.6%). Logistic regression analysis demonstrated that a young age at diagnosis (under 3 years), the use of heavy metal agents, a history of hematopoietic stem cell transplantation (HSCT), and combination treatment of chemotherapy, radiation therapy, and HSCT were associated with a significantly higher risk for overall dental abnormalities. The increased risk ratios were 6.00, 3.06, 3.22, and 7.87, respectively (p < 0.05). The results of this study will predict dental abnormality in permanent dentition according to the diagnosis age and treatment method of childhood cancer.
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KEYWORD
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Childhood cancer, Dental abnormality, Tooth agenesis, Microdontia, Abnormal root development
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